Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

Table 7

Other effects.

Experimental model	Dose	Effects and possible mechanism	Reference number
D-galactose-induced aging mice	42, 84, and 168 mg/kg	Improves the memory ability and regulates the body weight of mice; ↓ the levels of IGF-1; ↑ the expression of klotho	[132]
C. elegans	50 and 100 μM	Enhances the stress resistance; ↑ the life span of the nematode C. elegans	[1]
Rat cardiac fibroblasts	3–100 μmol/l	↓ ERK1/2 activation; ↓ overall production of ECM components	[133]
Pressure overload rats	60 and 120 mg/kg	↓ Angiotensin II level; ↓ transforming growth factor-β1 expression; ↓ ERK1/2 and p38 MAPK activation	[134]
Pressure overload rats	120 mg/kg	↑ Endogenous PPAR-γ expression	[17]
MC3T3-E1 cells	0.1–10 μM	↓ Osteoblastic differentiation; ↓ oxidative damage	[136]
SD rats	150, 300, and 600 mg/kg	↑ The density, content, and size of minerals in bone tissues; enhances the resistance to exogenic action, structural toughness, and strength of bone tissues	[137]