The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium
Formation and inhibition assays. FXa and thrombin production of 2 × 105 red blood cells (RBCs) (a), 2 × 104 platelets (PLTs) (b), 2 × 104 leukocytes (WBCs) (c), 10 ml MPs from each group (25 controls, 25 RVO patients) (d), and 2 × 104 endothelial cells (ECs) (e) is shown. Thrombin generation was examined in the existence of FXa and FVa. (f) The capacity of lactadherin (128 nM) to block procoagulant enzyme complexes on cells/MPs from 25 RVO patients or ECs incubated in RVO plasma was measured. versus controls.