Protective Effect of Increased Zinc Supply against Oxidative Damage of Sublingual Gland in Chronic Exposure to Cadmium: Experimental Study on Rats

Table 1

The impact of zinc on GSH, LPO, and H₂O₂ levels in the sublingual gland of rats exposed to cadmium.

	Nonenzymatic antioxidant; GSH; (nmol/mg of protein)	Oxidative stress index
		LPO; (nmol/mg of protein)	H2O2; (nmol/mg of protein)
Control	1.881 ± 0.800	0.122 ± 0.011	21.320 ± 2.343
30 mg Zn/dm^3	1.926 ± 0.181	0.095 ± 0.008	19.110 ± 0.617
60 mg Zn/dm^3	1.838 ± 0.570	0.093 ± 0.015	15.740 ± 1.336^a
5 mg Cd/dm^3	1.433 ± 0.086^a‡b‡c	0.263 ± 0.034^a†b‡c†	26.930 ± 1.000^a^b‡
5 mg Cd/dm^3 + 30 mg Zn/dm^3	1.933 ± 0.136^d†	0.113 ± 0.020^d†	17.480 ± 0.720^d‡
5 mg Cd/dm^3 + 60 mg Zn/dm^3	2.334 ± 0.144^a†b^c†d‡e†	0.104 ± 0.012^d†	18.020 ± 1.248^d‡
50 mg Cd/dm^3	1.340 ± 0.046^a†b‡c†e‡f‡	0.376 ± 0.066^a‡b‡c‡d^e‡f‡	41.800 ± 2.877^a‡b‡d‡f‡
50 mg Cd/dm^3 + 30 mg Zn/dm^3	1.715 ± 0.067^f‡g	0.233 ± 0.045^a^b†c†f^g†	21.860 ± 1.480^d^g‡
50 mg Cd/dm^3 + 60 mg Zn/dm^3	1.739 ± 0.052^f‡g	0.167 ± 0.023^d^e^g‡	17.540 ± 1.963^d‡g‡

The values are arithmetic means ± SEM. ; ; as compared to ^acontrol, ^b30 mg Zn/dm³, ^c60 mg Zn/dm³, ^d5 mg Cd/dm³, ^e5 mg Cd/dm³ + 30 mg Zn/dm³, ^f5 mg Cd/dm³ + 60 mg Zn/dm³, ^g50 mg Cd/dm³, and ^h50 mg Cd/dm³ + 30 mg Zn/dm³.