Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

Figure 3

Impact of 48 h treatments on lipid peroxidation in Caco-2 cells grown in (a) normal and (b) high glucose media. Bar charts display the mean ± SD of MDA ratio to respective glucose untreated control. The gray dashed line represents the level of normal glucose untreated control in relation to high glucose untreated control. Differences to the respective controls are statistically analyzed by Student’s t-test. Significance to untreated control (c) and respective H₂O₂ treatment (h) is marked with for , for , and for . Untreated controls are due to assay controls.

(a)

(b)