Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

Figure 8

Impact of 48 h treatments on global methylation in (a) normal and (b) high glucose grown Caco-2 cells. Bar charts display the mean ± SD of LINE-1 methylation levels. The gray dashed line represents the level of normal glucose untreated control in relation to high glucose untreated control. Differences to respective controls are statistically analyzed by Student’s t-test. Significance to untreated control (c) and respective H₂O₂ treatment (h) is marked with for .

(a)

(b)