Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease

<div>The effect of the NP-POL peptide on intracellular ROS generation induced by 6-OHDA. (a) NP-POL significantly reduced intracellular ROS levels in PC12 cells. (b) 6-OHDA induced an exponential increase in intracellular ROS in exposed cells. Both 1 h preincubation (c) with selected doses of NP-POL before 24 h of 6-OHDA exposure and 24 h of coincubation with NP-POL and 6-OHDA (d) resulted in a significant decrease in intracellular ROS levels. 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Results were considered significant at <svg height="14.9569pt" id="M15" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -11.5275 55.736 14.9569" width="55.736pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path></g><g transform="matrix(.013,0,0,-0.013,4.946,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease 