Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model
Table 3
Aortic dilation and wall thickness by optical coherence tomography analyses in WT and MFS mice with 1, 3, and 6 months of age.
WT1
MFS1
WT3
MFS3
WT6
MFS6
()
()
()
()
()
()
Aortic arch
Lumen (mm2)
6.0 ± 0.2
6.2 ± 0.1
6.8 ± 0.2
6.8 ± 0.1
7.7 ± 0.2a–c
12.2 ± 1.5c–g
Thickness (mm)
4.8 ± 0.2
5.0 ± 0.5
5.1 ± 0.6
5.1 ± 0.8
5.2 ± 0.2
7.4 ± 0.1c–f,h
Thoracic aorta
Lumen (mm2)
5.9 ± 0.2
6.1 ± 0.8
6.5 ± 0.2
6.6 ± 0.8
7.1 ± 0.2a
10.2 ± 0.3c,g,i–k
Thickness (mm)
3.8 ± 0.3
4.1 ± 0.5
3.9 ± 0.4
4.5 ± 0.8
4.0 ± 0.1
6.2 ± 0.6c–f,h
Abdominal aorta
Lumen (mm2)
5.8 ± 0.2
6.1 ± 0.1
6.0 ± 0.2
6.2 ± 0.1
6.5 ± 0.2
10.9 ± 0.8c,e,f,h,i
Thickness (mm)
3.7 ± 0.2
4.0 ± 0.4
3.9 ± 0.4
4.2 ± 0.6
6.1 ± 0.4k
8.3 ± 0.1d–g,l
WT: wild type; MFS: Marfan syndrome; 1: 1 month of age; 3: 3 months of age; 6: 6 months of age; a versus WT1; b versus MFS1; c versus MFS3; d versusWT1; e versus MFS1; f versus WT3; g versus WT6; h versus WT6; i versus WT1; j versus MFS1; k versus MFS3; l versus MFS3.
