Research Article
Comparison of Pulmonary and Systemic NO- and PGI2-Dependent Endothelial Function in Diabetic Mice
Figure 5
Endothelial dysfunction in systemic conduit vessel (aorta). (a, b) Impaired endothelium-dependent response to acetylcholine (ACh) with preserved endothelium-independent vasodilation in response to sodium nitroprusside (SNP) (control , diabetes ). (c) Preserved basal but impaired ionophore-stimulated production of nitrite in the aortic rings of diabetic mice (control , diabetes ). (d) Impaired basal production of prostacyclin as assessed by concentrations of its stable 6-keto-PGF1α product (control , diabetes ). Data are presented as the means ± SEM. .
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