Table 4: Relative normalized mRNA expression levels in brain homogenate from aged and aged POS-treated mice determined using quantitative real-time PCR in comparison to young control animals; mRNA expression of young control mice is 100%; ; mean ± SEM with one-way ANOVA and Bonferroni posttest with ; ; ; results are normalized to the mRNA expression levels of beta 2 microglobulin (B2M) and phosphoglycerate kinase 1 (PGK1).

AgedAged + POS

AMP-activated protein kinase (beta subunit)66.19 ± 6.0072.63 ± 8.38
cAMP response binding protein 1 (CREB1)64.27 ± 4.2963.28 ± 5.94
Citrate synthase (CS)66.75 ± 4.9261.35 ± 9.16
Complex I (CI)75.16 ± 3.3467.53 ± 7.60
Complex IV (CIV)58.89 ± 5.8060.97 ± 8.00
Glutathione peroxidase 1 (GPx-1)67.65 ± 8.7658.78 ± 8.18
Growth-associated protein 43 (GAP43)63.43 ± 9.2356.73 ± 8.13
Sirtuin 1 (Sirt1)74.71 ± 4.6575.36 ± 5.99
Superoxide dismutase 2 (SOD2)97.23 ± 5.2688.46 ± 10.39
Synaptophysin 1 (SYP1)83.23 ± 6.0872.26 ± 10.43