Review Article
Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation
Figure 2
Systemic depletion of kallistatin exacerbates aortic senescence. (a) Kallistatin depletion identified by genotyping with the expression of loxp, wild-type (WT) and deletion (del) alleles. (b) Western blot analysis of mouse kallistatin expression in the kidney of WT mice and KS−/− mice. (c) Representative images and quantitative analysis of β-gal staining of aorta sections from WT, KS−/− mice with or without STZ treatment. (d, e) PAI-1 and P16INK4a mRNA levels in mouse aorta. Values are expressed as mean ± SEM. . vs. the WT group, vs. the WT + STZ group.
(a) |
(b) |
(c) |
(d) |
(e) |