Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Figure 2

The alteration of EAAC1 protein (a), mRNA (b), and immunofluorescence density (c), xCT protein (d), mRNA (e), and immunofluorescence density (f) in the striatum after MnCl₂ exposure are shown in this figure (in vivo). Data expressed as mean ± SD for four mice in each group. Each RNA or protein preparation was run three times by real-time PCR or Western blotting; , denotes statistical significance compared with control group.

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