Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Figure 6

Model showing potential mechanisms of Mn-triggered oxidative damage in the striatum. Cysteine is a limiting substrate for GSH synthesis; EAAC1 and xCT are the transporters located in neurons and astrocytes, respectively. By inhibiting cysteine import, Mn disrupts GSH synthesis.