Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Table 3

Effects of Mn exposure and SSZ pretreatment on ROS and GSH levels in astrocytes.

Group	ROS (μmol/g pro)	GSH (μmol/g pro)
Control	191.51 ± 3.36	23.49 ± 5.37
100 μM MnCl2	199.62 ± 6.74	20.61 ± 6.72
200 μM MnCl2	254.69 ± 9.74	17.97 ± 3.12
400 μM MnCl2	296.46 ± 8.19	16.18 ± 3.11
200 μM SSZ + 400 μM MnCl2	324.86 ± 4.55^##	10.16 ± 0.71^#
1 mM NAC + 400 μM MnCl2	218.49 ± 7.04^##	20.61 ± 5.79^#

Data are mean ± SD; each. , denote statistical significance compared with the control group; , denote statistical significance compared with the MnCl₂ alone group.