Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice
Table 5
Effects of Mn exposure and AAH or SSZ pretreatment on MDA, sulfhydryl, and carbonyl levels.
Group
MDA (nmol/mg pro)
Carbonyl (nmol/mg)
Sulfhydryl (μmol/g)
Control
1.05 ± 0.42
3.08 ± 0.76
49.08 ± 6.18
12.5 mg/kg MnCl2
2.14 ± 0.57
5.8 ± 1.2
46.3 ± 7.45
25 mg/kg MnCl2
2.69 ± 0.76
7.48 ± 1.47
38.03 ± 2.12
50 mg/kg MnCl2
2.88 ± 0.88
8.19 ± 1.37
29.91 ± 7.08
500 mg/kg AAH + 50 mg/kg MnCl2
4.08 ± 0.99#
10.16 ± 1.72#
23.34 ± 3.09#
75 mg/kg SSZ + 50 mg/kg MnCl2
3.91 ± 0.71#
9.72 ± 0.94#
21.49 ± 4.92#
100 mg/kg NAC + 50 mg/kg MnCl2
2.03 ± 0.4#
6.19 ± 1.69##
39.02 ± 6.62##
Data are mean ± SD; each. , denote statistical significance compared with the control group; , denote statistical significance compared with the MnCl2 alone group.
