The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease

Table 2

Creatinine and products derived from nucleic acid oxidation.

	CKD 1	CKD 2	CKD 3	CKD 4	CKD 5
Plasma creatinine (μmol/L)	61.60 ± 14.21^a	90.33 ± 26.26^ab	142.87 ± 63.91^b	202.03 ± 53.21^b	590.40 ± 277.87^bc
Urinary creatinine (μmol/L)	12,494 ± 6926.21^a	10270.07 ± 6238.45^a	7359.17 ± 3882.42^b	6447.93 ± 4354.35^bc	4268.64 ± 5782.24^bc
eGFR	132.53 ± 33.21^a	76.98 ± 9.1^b	45.81 ± 8.5^c	24.73 ± 4.56^d	7.84 ± 2.9^e
Urinary 8-oxo-dGsn (μmol/L)	6.56 ± 5.11^a	5.14 ± 3.54^a	3.97 ± 2.58^ab	2.03 ± 1.46^b	1.92 ± 2.04^b
Urinary 8-oxo-Gsn (μmol/L)	10.87 ± 6.15^a	9.49 ± 4.74^ab	8.39 ± 5.52^ab	6.17 ± 3.78^bc	4.29 ± 2.62^bc
Urinary 8-oxo-dGsn/Cr (μmol/mol)	1.87 ± 0.87	1.92 ± 1.01	1.84 ± 0.81	1.47 ± 0.89	1.60 ± 1.59
Urinary 8-oxo-Gsn/Cr (μmol/mol)	3.07 ± 1.07^a	3.42 ± 1.34^a	3.72 ± 1.47^a	3.90 ± 1.93^b	3.75 ± 2.26^a
Plasma 8-oxo-Gsn (μmol/L)	0.17 ± 0.12^a	0.24 ± 0.18^ab	0.37 ± 0.20^b	0.49 ± 0.22^bc	1.10 ± 0.57^bcd
Plasma/urinary 8-oxo-Gsn	0.02 ± 0.02^a	0.03 ± 0.02^a	0.06 ± 0.04^a	0.10 ± 0.05^b	0.34 ± 0.03^bc

The data are expressed as the mean ± SD; letters indicate statistical significance (). CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; 8-oxo-dGsn: 8-oxo-7,8-dihydro-2-deoxyguanosine; 8-oxo-Gsn: 8-oxo-7,8-dihydroguanosine; Cr: creatinine.