Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity

Figure 3

Structural organization of the hippocampus from mice of control plus vehicle (0.9% NaCl, 1 ml/kg/day ip), control plus PDRN (8 mg/kg/day ip), CdCl₂ (2 mg/kg/day ip) plus vehicle, and CdCl₂ plus PDRN (HE stain). (a, A1, A2, b, B1, B2) In both control plus vehicle and control plus PDRN-treated mice, the normal morphology of the nervous tissue of the hippocampus, particularly in CA1 (arrowhead) and CA3 (arrow) areas, is evident. (c, C1, C2) In CdCl₂ plus vehicle-treated mice, neuronal loss and mild edema of the nervous tissue of the hippocampus, particularly in CA1 (arrowhead) and CA3 (arrow) areas, are evident. (d, D1, D2) In CdCl₂ plus PDRN-treated mice, the hippocampus and CA1 (arrowhead) and CA3 (arrow) areas in particular show a well-preserved neuronal architecture. (e) Quantitative evaluation of neurons in both CA1 and CA3 regions in the different groups of mice. versus both controls; ^† versus CdCl₂ plus vehicle (scale bar: a, b, c, ; A1, A2, B1, B2, C1, C2, D1, ).

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