Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOS/NO-Regulated Oxidative Stress
Aucubin attenuated cardiac hypertrophy and fibrosis post-MI. (a) Statistical analysis of heart weight (HW)/body weight (BW), HW/tibial length (TL), and lung weight (LW)/BW in the mice from indicated groups post-MI (). (b) H&E staining (left, ) and statistical analysis of the cross-sectional area (right, CSA, cells per experimental group). (c) The echocardiographic measurement of LVEDd and LVESd levels in the indicated mouse hearts post-MI (). (d) The relative mRNA levels of hypertrophic markers: ANP, BNP, β-MHC, and α-MHC in the indicated mice hearts post-MI (). (e) PSR staining and statistical analysis of the heart in the indicated mouse hearts post-MI (left, PSR staining; right, statistical analysis of the LV collagen volume (%), fields per experimental group). (f) The relative mRNA levels of fibrosis markers: collagen I and collagen III in the indicated mice hearts post-MI (). versus vehicle-sham and versus vehicle-MI.