2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1α/TGF-β/Smad2 Axis

Figure 1

Histological examination of hematoxylin-eosin sections of rat prostates. (a) Section taken from control rats showing normal histoarchitecture of the ventral prostates. (b) Section taken from the ventral prostate of testosterone-treated group exhibiting hypertrophy with increased epithelial thickness and intraluminar projections. (c) Section taken from the ventral prostate of the testosterone group cotreated with 50 mg/kg 2ME showing mild reduction in hypertrophy and hyperplasia. (d) Section taken from the ventral prostates of testosterone groups cotreated with 100 mg/kg 2ME showing obvious reduction in prostate hypertrophy and hyperplasia. (e) A graph showing the effect of 2ME cotreatment on prostate glandular epithelial height. Scale bar (50 μm). Data are expressed as mean ± SD (). a or b: statistically significant from control or testosterone group, respectively, at using one-way ANOVA followed by Tukey’s post hoc test.

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