More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis

Figure 2

Cell death mechanisms mediated by FTY720 in fission yeast. (a) FTY720 stimulates production of ROS, which causes growth defects. Cytotoxicity of FTY720 is more pronounced in the cells that lack the components of the SAPK signaling pathway. (b) FTY720 stimulates Ca²⁺ influx, thereby stimulating calcineurin signaling. Cells lacking the components of the Ca²⁺/calcineurin signaling pathway are hypersensitive to FTY720.

(a)

(b)