More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis

Figure 5

Strategies for combination therapy by manipulating ROS levels via FTY720-sensitive genes. (a) Functional categories of FTY720-sensitive genes and the concept of the synthetic lethality between mutations in FTY720-sensitive genes and FTY720 treatment. Mutation in the FTY720-sensitive genes induced elevated ROS levels. Combination of which is further increased upon FTY720 treatment. (b) Prooxidant therapy by combining (1) ROS generation by FTY720 and (2) antioxidant-inhibiting therapies by mutation in FTY720-sensitive genes.

(a)

(b)