Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid-β-Induced Toxicity in Rat Pheochromocytoma Cells

Figure 8

Schematic diagram shows anti-Aβ effects of LSPC on PC12 cells. CREB/BDNF signaling plays a significant role in neuronal growth, survival, and synaptic plasticity. Aβ can increase the apoptosis rates of cells and deform the cellular morphology since Aβ may lead to downregulation of CREB phosphorylation and BDNF expression. LSPC can reverse the effect of Aβ that it can improve the survival rates of cells and maintain the cellular morphology. LSPC may promote the upstream signaling of CREB/BDNF, including AKT and ERK phosphorylation, which can enhance CREB phosphorylation and BDNF expression. Additionally, Aβ may contribute to higher levels of MDA and LDH and the lower activity of T-SOD. LSPC can mitigate Aβ-induced damage through reducing the level of MDA and LDH and improving the activity of T-SOD. LSPC, procyanidins extracted from the lotus seedpod; Aβ, amyloid-β; PC12, rat pheochromocytoma cells; BDNF, brain-derived neurotrophic factor; CREB, cAMP-responsive element-binding; LDH, lactate dehydrogenase; SOD, superoxide dismutase; MDA, malonialdehyde.