The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases

Figure 1

TBP-2 suppresses cell growth in cancer disease. TBP-2 expression can be decreased by DNA methylation at CpG sites, histone deacetylation, and the complex of HDAC1, RFP, and NF-Y. Low expression of TBP-2 could not combine with JAB1 to restrain the translocation of p27^kip1 induced by JAB1; this results in increased p27^kip1 stability in the cytoplasm, whereby p27^kip1 cannot inhibit cell cycle procession. Meantime low TBP-2 cannot give assistance to the corepressor complex of PLZF, FAZF, and histone deacetylase 1 to induce cell cycle arrest. Moreover, when TBP-2 interacts with MIF, it could not suppress NF-κB activity since cancer cells migrate.