Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells

<div>NOX4, p22phox, and NOX5 modulate autophagy and apoptosis in ARPE-19 cells. (a–d) NOX4, p22phox, or NOX5 silencing inhibits autophagy and apoptosis. (e, f) siRNA knockdown of <i>NOX4</i>, <i>p22phox</i>, or <i>NOX5</i> decreases cell apoptosis. (g, h) siRNA knockdown of <i>NOX4</i>, <i>p22phox</i>, or <i>NOX5</i> decreases ROS production. Intracellular ROS was evaluated by flow cytometry. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells 