Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress

Figure 2

Accumulation of lactate in the bloodstream during constant load test. (a) Lactate accumulation in the blood during a 28-minute constant load test (at 85% of maximal speed reached during the incremental test). The vertical dashed line represents the time point in which final blood lactate concentration (plotted in panel (b)) was evaluated. , as evaluated by two-way ANOVA (differences among paired curves); , CASQ1-null versus WT, and , CASQ1-null versus CASQ1-null trained, as evaluated by Bonferroni’s post hoc test (indicating differences among the same time point). (b) Average blood lactate concentration at the end of incremental test (28th minute; dashed line in panel (a)). Data are given as mean ± SD; , as evaluated by one-way ANOVA followed by Tukey’s post hoc test. n = number of mice.

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