Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress

Figure 4

Mortality rate and measurements of core temperature in mice exposed to heat stress. (a) Incidence of sudden and delayed deaths (i.e., within 24 h after challenge) following exposure to the heat stress protocol (41°C for 1 h); , as evaluated by two-tailed Fisher’s exact test. (b) Table showing (i) the number of mice tested during the heat challenge and (ii) the experimental outcome. (c) Increase in absolute core temperature, recorded every 5 minutes during exposure to the heat stress protocol: dashed vertical line represents the mean time-to-onset of lethal crises in CASQ1-null mice; , trained CASQ1-null versus both WT and trained CASQ1-null mice, as evaluated by two-way ANOVA followed by Bonferroni’s post hoc test. (d) Average core temperature in mice at 45th minute of the heat stress protocol (dashed line in panel (c)). Data in (c) and (d) are given as mean ± SD; , as evaluated by one-way ANOVA followed by Tukey’s post hoc test. n = number of mice (in panel (d)).

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