The Potential Roles of Extracellular Vesicles in Cigarette Smoke-Associated Diseases

Table 1

Potential biomarkers of EVs and exosomes in response to cigarette smoke in chronic diseases.

Components	Species	Sources	Vesicle	Disease	Reference
miRNA
miR-378a, miR-379,; miR-139-5p,; miR-200b-5p	Human	Plasma	Exosome	Lung cancer	[64]
miR-7, miR-20a, miR-28-3p,; miR-34c-5p, miR-100	Human	Serum	Exosome	COPD	[65]
let-7d, miR-191; miR-125a, miR-126	Human; Mouse	Cell supernatant; Plasma	Endothelial microparticles (EMPs)	COPD	[8]
let-7e, let-7g, miR-26b	Human	Bronchoalveolar lavage (BAL)	EVs	COPD; Lung cancer	[14]
miR-210	Human	Cell supernatant	EVs	COPD	[10]
miR-223, miR-29b	Human	Plasma	Microvesicle	CVD	[31]
Protein
LRG1	Human	Urine	Exosome	NSCLC	[66]
μ-Calpain, m-calpain	Human	Cell supernatant	Vesicles	Lung cancer	[11]