Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo
Propofol postconditioning protected hepatocyte from apoptosis. Fluorescent TUNEL staining of liver tissue (40x) (a). Cleaved caspase-3 and procaspase-3 proteins were detected by Western blot method (b). The amount of target proteins cleaved caspase-3 and procaspase-3 was calculated by gray scanning and was analyzed (c). The results are expressed as the mean ± SD. per group. vs. the sham group; and vs. the OALT group. HPro = high dose of propofol; LPro = low dose of propofol; INT = intralipid; VAS = VAS2870; OALT = orthotopic autologous liver transplantation.
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