SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

Figure 5

SS-31 promoted the mitochondrial biogenesis potentially via the PGC-1α pathway. (a, d) Immunohistochemical staining showed the nuclear PGC-1α and SIRT1 positive neurons which were marked by the red arrows. (b) Western blot assay showed the nuclear and total PGC-1α expression. (c) Relative protein levels of PGC-1α were normalized to the level of H3. These showed the nuclear translocation of PGC-1α after SS-31 treatment. (e) Western blot assay showed the restoration of SIRT1 expression. (f) Relative protein levels of SIRT1 were normalized to the level of β-actin. per group. Scale bar 50 μm. Data are presented as mean ± SEM; , versus the sham group; versus the TBI + vehicle group.

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