Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine

Figure 2

(a) Carbon dioxide production over 8 hours of breathing in mice exposed to normoxia (control) or hypoxia. Carbon dioxide production (mean ± SEM) in mice expressed as ml per minute per gram body mass (ml/min/g) over the 480-minute (8 hour) period of exposure to either normoxia (FiO₂ = 0.21, ) or hypoxia (FiO₂ = 0.10, ); two-way (time × gas treatment) ANOVA and Bonferroni’s multiple comparisons test. and compared with corresponding normoxic values. (b) Postmortem body temperatures in mice following 8 hours of exposure to normoxia (control), hypoxia, or hypoxia + NAC. Postmortem body temperatures (mean ± SEM) of mice exposed to 8 hours of normoxia (FiO₂ = 0.21, ), hypoxia (FiO₂ = 0.10, ), or hypoxia + NAC (200 mg/kg i.p. at FiO₂ = 0.10, ). , unpaired t test compared with control; , unpaired t test with Welch’s correction compared with control.

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