Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine

Figure 3

Minute ventilation (), ventilatory equivalent for carbon dioxide (), and respiratory exchange ratio (RER; ) during 8 hours of exposure to normoxia (control) or hypoxia. (a) Minute ventilation (mean ± SEM) expressed as ml per min per gram body mass (ml/min/g) over the 480-minute (8 hour) period of exposure to either normoxia (FiO₂ = 0.21, ) or hypoxia (FiO₂ = 0.10, ); two-way ANOVA (time × gas treatment) and Bonferroni’s multiple comparisons test, compared with corresponding normoxic value. (b) Ventilatory equivalent ratio (mean ± SEM) in mice over the 480-minute (8 hour) period of exposure to either normoxia (FiO₂ = 0.21, ) or hypoxia (FiO₂ = 0.10, ); two-way ANOVA (time × gas treatment) and Bonferroni’s multiple comparisons test, and compared with corresponding normoxic value. (c) Respiratory exchange ratio (mean ± SEM) in mice over the 480-minute (8 hour) period of exposure to either normoxia (FiO₂ = 0.21, ) or hypoxia (FiO₂ = 0.10, ); two-way ANOVA (time × gas treatment).

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