Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine

Figure 6

Mouse diaphragm mTOR, phospho-mTOR, phospho-ERK1/2, and phospho-FOXO3a protein contents following 8 hours of exposure to normoxia (control), hypoxia, or hypoxia + NAC. (a) Diaphragm mTOR protein content (mean ± SEM) expressed as signal/μg of total protein (corrected for background signal); per group. and ; unpaired t tests. (b) Diaphragm phospho-mTOR protein content (mean ± SEM) expressed as signal/μg of total protein (corrected for background signal); per group. , , and ; unpaired t tests. (c) Diaphragm phospho-FOXO3a protein content (mean ± SEM) expressed as signal/μg of total protein (corrected for background signal); per group. , , and ; unpaired t tests.

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