Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

<div>Clock and antioxidative gene expression was altered in the striatum of 6-OHDA-lesioned rats. (a) Expression of <i>Bmal1</i>. (b) Expression of <i>Per2</i>. (c) Expression of <i>Clock</i>. (d) Expression of <i>Rorα</i>. (e) Expression of <i>Cat</i>. (f) Expression of <i>Gpx</i>. (g) Expression of <i>Sod</i>. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease 