Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice

Figure 1

Effects of TRPC5 deletion and TRPC4/TRPC5 antagonism in the severity, body temperature, and weight of SIRS mice. (a) Severity of SIRS, (c) drop in body weight, and (e) temperature in TRPC5^+/+ and TRPC5^−/− mice injected with vehicle (PBS; ) or lipopolysaccharide (LPS; ). (b) Severity of SIRS, (d) drop in body weight, and (f) temperature in mice treated with vehicle (6% DMSO in PBS; ) or the TRPC4/TRPC5 antagonist ML204 (1 mg/kg; ) subcutaneously, twice a day, for 5 days prior to LPS injection. Non-SIRS (PBS-injected) mice were used as controls (). differs from vehicle-injected controls; differs from LPS-injected controls.

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