Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice

Figure 2

Effects of TRPC5 deletion and TRPC4/TRPC5 antagonism in organ failure and survival of SIRS mice. Circulating (a) aspartate aminotransferase (AST) and (c) creatinine levels in TRPC5^+/+ and TRPC5^−/− mice injected with vehicle (PBS; ) or lipopolysaccharide (LPS; ). Circulating levels of (b) AST and (d) creatinine in mice treated with vehicle (6% DMSO in PBS; ) or the TRPC4/TRPC5 antagonist ML204 (1 mg/kg; ) subcutaneously, twice a day, for 5 days prior to LPS injection. Non-SIRS (PBS-injected) mice were used as controls (). Survival rates (e) were registered in SIRS and non-SIRS mice administered with vehicle or ML204 (/group). differs from vehicle-injected controls.

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