Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps

Figure 7

Sal B and DHT I synergistically attenuate the formation of NETs. (a) The effects of DSI, Sal B, DHT I, or the combination of Sal B and DHT I on the cell vitality in BGC-823 gastric cancer cells for 48-hour treatment. or as shown in the indicated comparison. (b) Human neutrophils were activated by PMA (200 ng/mL) in the presence of DPI, DSI, Sal B, DHT I, or combination of Sal B or DHT I on NETosis by plate reader assay. between control and drug treatment. or as shown in the indicated comparison. (c) Analysis of drug combinations using median-effect equation and CompuSyn software. or as shown in the indicated comparison.

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