Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

<div>DpdtC induced iron mobilization from ferritin. (a) The absorbance spectrum of DpdtC and its iron complex; the profiles of iron extracting from ferritin by DpdtC were also included; (b) the spectral changes of ferritin during addition of DpdtC. The insert showed the absorbance changes at specific wavelengths (350 and 404 nm); (c) iron mobilization from ferritin by different concentrations of DpdtC was assayed by measuring the absorbance difference at 404 nm, and effect of SOD on iron mobilization was conducted in a similar way.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation 

Figure 1 | Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation 