Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

Figure 4

DpdtC induced formation of acidic vesicular organelles autophagy; the HepG2 cells were treated by the indicated agents for 24 h. (a) Control; (b) 1 μM DpdtC; (c) 2 μM DpdtC; (d) 1 μM DpdtC + 3-MA; (e) 2 μM DpdtC + 3-MA(2.5 mM); (f) 1 μM DpdtC + Fe²⁺(1 μM); (g) 2 μM DpdtC + Fe²⁺(2 μM), scale bar: 50 μm.

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