Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

Figure 8

DpdtC induced change in lysosomal membrane permeability (LMP). LysoTracker Red stained HepG2 cells: (a) control; (b) 1.0 μM DpdtC; (c) 1.0 μM DpdtC + NAC (1.5 mM). (d) 1.0 μM DpdtC + 3-MA (1.5 mM); (e) 1.0 μM DpdtC + DFO (50 μM); (f) 1.0 μM DpdtC + CQ (50 μM). Scale bar: 50 μm.

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