From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs

Figure 2

MicroRNAs predicted to target genes involved in the pathways modulated by oxidative stress. We added to the previous simplified flow diagram (shown in Figure 1) the miRNAs that we predicted to be putative novel actors in oxidative stress responses (shown in Table 3) and grouped them according to their common gene targets and overall relationship to cellular pathways/responses. 1 = miR-195, miR-424, miR-15a/b, and miR-497; 2 = miR-106a/b, miR-17, miR-20a/b, miR-93, and miR-519d; 3 = miR-124 and miR-506; 4 = miR-655, miR-548c-3p, and miR-101; 5 = miR-519a/b-3p/c-3p, miR-590-3p, and miR-513a-3p; 6 = miR-548n, miR-23a/b, and miR-27a/b; 7 = miR-548p and miR-429; and 8 = miR-548n and miR-27a/b.