Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

Figure 2

The effects of METH on DAT. METH impairs DAT activity either via direct inhibition or via reverting its direction. Such an effect potentiates the accumulation of freely diffusible DA in the extracellular space and prevents the main mechanisms of DA removal (reuptake within DA terminals).