Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

Figure 3

The effects of METH on mitochondria. METH impairs the activity of complex II of the mitochondrial respiratory chain and directly inhibits MAO-A placed on the outer mitochondrial membrane within DA terminals. METH also inhibits MAO-B placed extracellularly at the level of glia. However, the affinity of METH for MAO-B is tenfold less when compared with MAO-A. Thus, MAO-B inhibition does not influence that much the amount of extracellular DA.