Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

Figure 4

The effects of METH-induced MAO-A inhibition on DA metabolism. The loss of physiological DA deamination following MAO-A inhibition and its uncoupling with AD lead to the generation of highly reactive species including DOPALD (1), hydrogen peroxide (H₂O₂), and DA quinones (2).