Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

Figure 5

Quercetin as a direct inhibitor of mTOR kinase. (a) In vitro kinase assay showing a dose-dependent inhibition of mTOR activity by quercetin. (b) Structural modeling of interactions of quercetin with the ATP-binding pocket of mTOR.

(a)

(b)