Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers
Table 1
Cytotoxicity assessment of compounds isolated from C. tincturia.
Cpd
Percent viability
0.01 μM
0.1 μM
1 μM
10 μM
100 μM
MCF-7
1
95.8 ± 1.6
91.5 ± 3.4
88.6 ± 3.3
84.8 ± 1.6
78.8 ± 0.3
2
99.4 ± 1.2
94.8 ± 3.3
91.1 ± 3.2
90.3 ± 2.4
85.9 ± 1.6
3
99.1 ± 0.3
95.1 ± 3.4
94.0 ± 2.5
92.8 ± 1.7
90.5 ± 0.3
4
99.8 ± 0.5
96.0 ± 0.5
94.5 ± 3.1
91.1 ± 2.4
87.9 ± 0.6
5
98.3 ± 1.2
91.8 ± 2.7
88.9 ± 2.8
86.9 ± 1.7
80.2 ± 1.2
6
97.5 ± 1.5
93.2 ± 3.8
90.4 ± 3.4
88.2 ± 2.1
80.3 ± 1.7
SAOS-2
1
98.9 ± 0.8
95.1 ± 0.9
92.1 ± 0.9
80.4 ± 0.9
70.1 ± 0.2
2
99.2 ± 0.6
97.4 ± 2.0
94.5 ± 1.3
92.8 ± 1.6
89.3 ± 1.5
3
97.4 ± 1.0
96.8 ± 0.9
91.9 ± 1.7
84.7 ± 3.4
66.2 ± 1.2
4
98.4 ± 0.7
95.8 ± 0.8
92.7 ± 0.4
90.1 ± 0.9
84.7 ± 1.0
5
97.0 ± 1.5
92.9 ± 0.8
90.9 ± 0.5
85.4 ± 0.5
77.1 ± 0.5
6
96.6 ± 0.8
93.6 ± 0.7
92.6 ± 1.9
88.5 ± 1.2
76.2 ± 0.9
MG-63
1
88.2 ± 0.1
82.3 ± 1.2
74.9 ± 2.0
61.3 ± 0.4
40.4 ± 0.5
2
95.9 ± 2.7
88.8 ± 2.0
81.1 ± 0.3
74.9 ± 1.4
70.9 ± 0.6
3
96.7 ± 2.0
92.2 ± 1.6
87.4 ± 1.2
80.8 ± 0.2
64.3 ± 1.1
4
98.1 ± 0.4
93.2 ± 1.3
87.2 ± 0.8
79.8 ± 2.0
60.2 ± 1.7
5
93.1 ± 0.9
83.4 ± 1.2
78.1 ± 0.8
67.7 ± 1.1
54.7 ± 2.1
6
91.1 ± 0.7
86.2 ± 0.8
82.2 ± 1.2
73.0 ± 1.2
63.4 ± 0.4
Cells were treated with test compounds for 72 h and viability was determined using SRB assay. Data are expressed as mean ± SD; . Significantly different from control untreated cells ().
