Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT

Figure 4

Liver activities of CAT (a), SOD (b), GPX (c), GR (d), NQO1 (e), GST (f), and GGT (g) in mice subjected to control diet (CD) and high-fat diet (HFD) without (−) and with eicosapentaenoic acid (EPA), hydroxytyrosol (HT), and EPA + HT supplementation. Values are for 8 animals per experimental group. Groups sharing the same symbol are not significantly different among them according to two-way ANOVA and the Bonferroni posttest (). CAT: catalase; SOD: superoxide dismutase; GPX: glutathione peroxidase; GR: glutathione reductase; NQO1: NADPH-quinone oxidoreductase 1; GST: glutathione-S-transferase; GGT: γ-glutamyl transpeptidase. ^, and indicate the significant differences between the experimental groups.

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