Antihypertensive Effect of Ethanolic Extract from Acanthopanax sessiliflorus Fruits and Quality Control of Active Compounds

Figure 10

Effects of DHP1501 on serum renin (a) and ACE concentrations (b). (a) Changes in renin concentration induced by DHP1501. (b) Changes in ACE concentration induced by DHP1501. Groups included the following: WKYs as normal control; SHR (saline as the vehicle); SHR-captopril 100 (a 4-week daily course of oral captopril at a dose of 100 mg/kg); SHR-DHP1501 200 (a 4-week daily course of oral DHP1501 at a dose of 200 mg/kg); SHR-DHP1501 400 (a 4-week daily course of oral DHP1501 at a dose of 400 mg/kg); and SHR-DHP1501 600 (a 4-week daily course of oral DHP1501 at a dose of 600 mg/kg). Values were expressed as the mean ± SD (/group) (, versus the WKY group; , versus the SHR group).

(a)

(b)