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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 5179468, 9 pages
Research Article

Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

Zhen Wang,1,2,3 Menglong Wang,1,2,3 Jianfang Liu,1,2,3 Jing Ye,1,2,3 Huimin Jiang,1,2,3 Yao Xu,1,2,3 Di Ye,1,2,3 and Jun Wan1,2,3

1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
2Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China
3Hubei Key Laboratory of Cardiology, Wuhan 430060, China

Correspondence should be addressed to Jun Wan; moc.621@3691nujnaw

Received 21 September 2017; Revised 6 December 2017; Accepted 18 December 2017; Published 28 February 2018

Academic Editor: Mariateresa Giuliano

Copyright © 2018 Zhen Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Zhelan Zheng, Jiasheng Bao, Chen Ye, and Zhengwen Zhou, “Fmr1 protects cardiomyocytes against lipopolysaccharide‑induced myocardial injury,” Experimental and Therapeutic Medicine, vol. 16, no. 3, pp. 1825–1833, 2018. View at Publisher · View at Google Scholar
  • Zhengquan Huang, Bo Xu, Xiaochen Li, Jun Mao, Songjiang Yin, Li Zhang, Liang Ding, and Peimin Wang, “Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction,” Journal of Inflammation (United Kingdom), vol. 15, no. 1, 2018. View at Publisher · View at Google Scholar
  • Zhen Wang, Yao Xu, Menglong Wang, Jing Ye, Jianfang Liu, Huimin Jiang, Di Ye, and Jun Wan, “TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice,” EBioMedicine, 2018. View at Publisher · View at Google Scholar
  • Mengmeng Xu, Yanbei Zhang, Muyun Wang, Hai Zhang, Yuqing Chen, Ian M. Adcock, Kian Fan Chung, Jinhan Mo, Yinping Zhang, and Feng Li, “ TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM 2.5 ) ,” Oxidative Medicine and Cellular Longevity, vol. 2019, pp. 1–15, 2019. View at Publisher · View at Google Scholar
  • Simona Giorgi, Magdalena Nikolaeva-Koleva, David Alarcón-Alarcón, Laura Butrón, and Sara González-Rodríguez, “Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?,” International Journal of Molecular Sciences, vol. 20, no. 12, pp. 2906, 2019. View at Publisher · View at Google Scholar
  • M.F. Nagoor Meeran, Hasan Al Taee, Sheikh Azimullah, Saeed Tariq, Ernest Adeghate, and Shreesh Ojha, “β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats,” Chemico-Biological Interactions, 2019. View at Publisher · View at Google Scholar