Relevance of Alternative Routes of Kynurenic Acid Production in the Brain

Table 2

Enzymes involved in KYNA production from D- and L-enantiomers under different oxygen conditions.

	D-Trp → D-Kyn → KYNA	L-Trp → L-Kyn → KYNA	D-Trp → IPA	IPA → L-Trp
α-Ketoglutarate-eliminating system	✓	✘
Aerobic conditions	✓	✓	✓	✓
Anaerobic conditions	✘	✓	✘	✓
Enzyme involved	DAAO	Transaminase	Oxidase	Transaminase