Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition
Expression of MsrB1 in tissues and cell lines of HCC. (a) MsrB1 mRNA expression was elevated in 6 HCC tumors than in 9 normal liver tissues detected by RT-PCR. (b) MsrB1 mRNA expression was increased in HepG2, Hep3B, LM3, and BEL-7402 cell lines than in HL-7702 detected by RT-PCR. (c) MsrB1 mRNA expression was increased in HepG2, Hep3B, BEL-7402, BEL-7404, and BEL-7405 cell lines than in HL-7702 detected by q-PCR (). (d) The DNA copy number assay showed that the MsrB1 copy number was stepped up in HCC tissues than in adjacent normal tissues. (e) The MsrB1 expression level was increased in HepG2, Hep3B, LM3, snu387, SK-hep1, and BEL-7402 and decreased in Huh7 and SMMC-7721 detected by Western blotting.