Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition

<div>MsrB1 induced apoptosis and cell cycle arrest of HCC cells. (a, c) Knockdown of MsrB1 enhances H<sub>2</sub>O<sub>2</sub>/trx-induced apoptosis of LM3 cells. (b, c) Knockdown of MsrB1 enhances apoptosis of snu387 cells. (d) Mitochondrial integrity completely disappeared in HCC cells due to MsrB1 knockdown, resulting in the fragmentation of some mitochondria. (e, f) Knockdown of MsrB1 induced S/G2 phase arrest and G1 phase decrease.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4: Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition 

Figure 4 | Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition 